GLIDAPA TENMET 500 by Steris Healthcare: Dapagliflozin, Teneligliptin & Metformin ER Tablets Uses, Benefits & Dosage

 Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets are used to improve blood sugar control in adults with type 2 diabetes mellitus. The combination is usually prescribed when diet, exercise and one or two antidiabetic medicines have not brought blood sugar to target. It brings together three medicines with three different actions in one tablet: an SGLT2 inhibitor (dapagliflozin), a DPP-4 inhibitor (teneligliptin) and a biguanide (metformin). GLIDAPA TENMET 500 from Steris Healthcare is intended for patients whose doctor has decided that this fixed combination suits them. It is not for type 1 diabetes.

Why Is Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets Important?

Type 2 diabetes is progressive. Over time the pancreas makes less insulin and the body becomes more resistant to it, so a single medicine often stops being enough. Persistently high blood sugar damages the eyes, kidneys, nerves and blood vessels, and it raises the risk of heart disease.

This combination is important because it attacks the problem from three directions at once. Metformin lowers the liver’s sugar output and improves insulin sensitivity. Teneligliptin helps the body release insulin in response to meals. Dapagliflozin removes extra glucose through the urine, independent of insulin. Together, the three can lower both fasting and after-meal sugar more than any one alone. Replacing three separate tablets with one also makes the daily routine simpler, and this can improve adherence. The extended-release metformin is gentler on the stomach than immediate-release metformin. GLIDAPA TENMET 500 is manufactured by Steris Healthcare, a WHO-GMP and ISO-certified manufacturer in Jaipur, which supports consistent quality in a long-term therapy.

Key Benefits of Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets

What Are the Benefits of GLIDAPA TENMET 500?

  • Lowers fasting and post-meal blood sugar and HbA1c through three complementary actions
  • Dapagliflozin may support modest weight loss and a small reduction in blood pressure
  • Dapagliflozin has shown heart and kidney protective benefits in clinical studies of people with type 2 diabetes
  • Teneligliptin and dapagliflozin have a low risk of causing hypoglycaemia when used without insulin or sulphonylureas
  • Metformin is weight-neutral and has a long record of safety and cost-effectiveness
  • The extended-release form improves stomach tolerance and supports once-daily dosing
  • One tablet replaces several, which helps patients stay on treatment

Mechanism of Action

  • Dapagliflozin blocks SGLT2 in the kidney’s proximal tubules. This reduces the reabsorption of filtered glucose, so the excess sugar leaves in the urine.
  • Teneligliptin inhibits the enzyme DPP-4. This increases active incretin hormones (GLP-1 and GIP), which boost insulin release and reduce glucagon in a glucose-dependent way.
  • Metformin hydrochloride (extended release) reduces glucose production in the liver, improves insulin sensitivity in muscle and fat, and slightly reduces glucose absorption from the gut. The extended-release design releases the drug slowly over many hours.

Dosage Guidelines for Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets

Dosing must be decided by the treating doctor.

  • Usual dose: one tablet once daily, or as prescribed.
  • How to take it: swallow the tablet whole with water, with a meal. Taking it with the main meal usually reduces stomach side effects. Do not crush, cut or chew it, because this breaks the extended-release action.
  • Fixed dose: because the strengths are fixed, it is meant for patients already stable on these dose levels of each drug. Patients who need different strengths should be prescribed the components separately.
  • Monitoring: HbA1c, fasting and post-meal sugar, kidney function (eGFR), vitamin B12 and blood pressure should be checked regularly.
  • Stay hydrated and keep to your diet and exercise plan.
  • Missed dose: take it when remembered, unless it is nearly time for the next one. Do not double the dose.
  • Before surgery, fasting or contrast scans: your doctor may ask you to pause it temporarily.

Side Effects of Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets

Common effects include:

  • Increased urination and thirst
  • Genital itching or yeast infection
  • Urinary tract infection
  • Nausea, diarrhoea, stomach upset or a metallic taste
  • Headache or dizziness
  • Mild weight loss
  • Low blood sugar, especially if taken with insulin or sulphonylureas

Serious Side Effects of Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets

Seek urgent medical help for:

  • Fast breathing, unusual tiredness, muscle pain, stomach pain or cold hands and feet (lactic acidosis)
  • Nausea, vomiting, abdominal pain, excessive tiredness or breathing difficulty, even with normal blood sugar (ketoacidosis)
  • Pain, redness, swelling or fever in the genital or anal area (Fournier’s gangrene, a rare but serious infection)
  • Severe or persistent abdominal pain that may spread to the back, with or without vomiting (pancreatitis)
  • Fever, flank pain or burning urine that does not settle (kidney infection)
  • Dizziness, fainting or very low urine output (dehydration)
  • Palpitations, or fainting, or an irregular heartbeat
  • Blistering skin, joint pain or severe allergic reactions

Available Substitutes for Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets

Other brands containing the same three-drug combination may be available, so ask your pharmacist for the same composition and strength. Doctors may also prescribe the medicines as separate tablets, or as two-drug combinations such as dapagliflozin with metformin, which allows each dose to be adjusted. Other combinations that use different molecules are not direct substitutes. Do not switch brands or components without medical advice.

Precautions & Warnings with Using Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets

  • Do not use it in type 1 diabetes or diabetic ketoacidosis.
  • Do not use it if you are allergic to any ingredient.
  • Avoid it in severe kidney impairment and in severe liver disease. Your doctor will check eGFR before and during treatment.
  • Avoid it in conditions that raise the risk of lactic acidosis, such as heart failure with poor perfusion, severe infection, dehydration or heavy alcohol use.
  • Stop it temporarily before iodinated contrast scans, major surgery or prolonged fasting, as advised by your doctor.
  • Use caution in people with a history of pancreatitis, genital or urinary infections, low blood pressure or those on diuretics, because of the risk of volume depletion.
  • Use caution in patients with a prolonged QT interval, or those taking QT-prolonging medicines, because of teneligliptin.
  • Long-term metformin can lower vitamin B12, so periodic checks are advised.
  • Limit alcohol. Keep your feet and genital area clean and dry.
  • Pregnancy and breastfeeding: it is generally not recommended, so speak to your doctor about alternatives such as insulin.
  • Tell your doctor about all medicines you take, including insulin, sulphonylureas, diuretics, corticosteroids and cimetidine.

Conclusion

Dapagliflozin 10 mg, Teneligliptin 20 mg & Metformin Hydrochloride 500 mg (Extended Release) Tablets, supplied as GLIDAPA TENMET 500 by Steris Healthcare, combine three complementary mechanisms in one tablet to support better blood sugar control in adults with type 2 diabetes. Used with a healthy diet, regular activity, hydration and routine monitoring of kidney function and blood sugar, it can help patients reach their targets with a simpler daily regimen.

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